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Nencki Conference
for Life Sciences

Focus on Lipid Metabolism

About conference

Nencki Conference for Life Science – Focus on Lipid Metabolism

Lipids represent the most energy-dense component of our diets. Therefore,  they serve as the most desirable material to store energy. Apart from acting as fuel molecules, different lipids play multiple structural and signaling functions in the cells. Lipid overload or defects in the enzymatic and signaling machinery regulating lipid handling cause multiple disorders ranging from metabolic diseases (obesity, diabetes, atherosclerosis, and metabolic fatty liver disease), through different types of cancers to immune disorders.  Our understanding of the molecular mechanisms governing different aspects of lipid metabolism is far from being completed. Moreover, the role of lipid metabolism in pathophysiology of many processes is not completely understood. Thus the Nencki Conference for Life Science will focus this year on lipid metabolism. The meeting will cover  multiple aspects connected to the metabolism of lipids:

  • Role of lipid droplets in the regulation of cellular metabolism and response to stress
  • Lipid metabolism in carcinogenesis
  • The impact of lipids on the immune response
  • Pathophysiological processes caused by dysregulation of lipid handling
  • Technical advances in  the identification of processes regulating lipid homeostasis.

Nencki Conference will provide a unique opportunity for discussion of cutting-edge science between researchers at different stages of their careers. Four lecture sessions and two poster events will provide an opportunity networking and the exchange of scientific ideas.

Nencki Conference for Life Science Series

The Nencki Institute is a flagship research institution of the Polish Academy of Sciences. Conferences and workshops Organized by Nencki Institute focus on scientific excellence and propagate international networking, equality, and diversity.

Main informations

Venue: CN Conference Hall at Nencki Institute of Experimental Biology of the Polish Academy of Sciences (3 Pasteur Street, 02-093 Warsaw, Poland).

The conference fee is based on the type of registration: Young Scientist – PhD students (50€), Academic (100€), Non-academic (100€).

Thank you all for submissions and abstracts.  Abstracts will be assessed by Scientific Board until April 30th 2024.

We would like to inform you about the extension of registration for passive or active – poster participation deadline.

You can still register on  https://conference.nencki.edu.pl/registration until May 10th 2024, 23.59.59 CET

Program

Thursday

  • Registration

  • Opening remarks

    Agnieszka Dobrzyń
    Grzegorz Sumara

  • Session 1 - Lipid droplets in (not only lipid) homeostasis

    Grzegorz Sumara (chair)

    • Keynote lecture - Cellular mechanisms of lipid homeostasis: From lipid droplets to ferroptosis

      James Olzmann

    • Short break

    • Long talk - Lipid droplets – managing fat in the battle against stress

      Toni Petan

    • Short talk – Physiological ordered packing of cholesterol easters in lipid droplets in mammalian tissue described by Cryo Serial Lift-Out

      Wioleta Dudka

    • Short talk – Mechanisms of lipid-evoked regulation of lipid droplet proteostasis in the small intestine

      Magdalena Wit

    • Short talk – Vasoprotetive activity of ATGL-dependent lipolysis and cPLA2- PGI2 pathway in the context of postprandial endothelial dysfunction

      Magdalena Sternak

    • Short talk – Lipid droplets in vascular wall - an integral component of vascular response to endothelial inflammation

      Marta Pacia

    • Flash Talk - Unraveling translation surveillance pathways of brown adipocytes

      Toufic Kassouf

    • Flash Talk - Proteomic approach unravels E3 ligase, TRIM32, as a central mediator β-adrenergic signalling in adipocytes

      Katia Al Ghoz

    • Flash Talk - Loss of unconventional myosin VI affects lipid metabolism in hindlimb skeletal muscle

      Lilya Lehka

  • Corporate presentation (TSE Systems and AnimaLab): New trends in automated metabolic, behavioral, and physiological phenotyping of rodents

    Holger Russig, PhD

  • Lunch break and Poster session 1

    • 1. Proteomic approach unravels E3 ligase, TRIM32, as a central mediator β-adrenergic signalling in adipocytes

      Katia Al Ghoz

    • 2. Oxidized phosphatidylcholine derivatives regulate endocytosis and secretion of CD14 in mouse macrophages

      Ichrak Ben Amor

    • 3. Role of fatty acids metabolized by stearoyl-CoA desaturase in cardiomyocyte maturation

      Volodymyr Balatskyi

    • 4. Cholesterol content in brains of suicide completers

      Monika Czapiewska

    • 5. The potential benefits of using ACAT inhibitor in 5-fluorouracil-based colon cancer therapy – an in-vitro study

      Aleksandra Czumaj

    • 6. Metformin reduces palmitotoxicity by promoting perilipin 5-mediated lipid droplet-mitochondria coupling in pancreatic β-cells

      Aneta Dobosz

    • 7. GIP_HUMAN[22-51] suppresses glucagon mRNA expression and proliferation in alpha TC1 cells

      Joanna Fiedorowicz

    • 8. Characterization of the in vitro model of obesity based on human adipocytes

      Katarzyna Pietraszek-Gremplewicz

    • 9. Inhibition of stearoyl-CoA desaturase 1 activity controls mitochondrial damage and bioenergetics by regulating cardiolipin composition in palmitate-stressed pancreatic β-cells

      Justyna Janikiewicz

    • 10. Protein Kinase D2 promotes chylomicron-mediated transport of triglycerides

      Freeha Kanwal

    • 11.Unraveling translation surveillance pathways of brown adipocytes

      Toufic Kassouf

    • 12. Towards understanding metabolic sgnificance of PACS-2 E209K mutation. A comparison of lipid profile in fibroblasts from PACS-2 syndrome patient versus healthy twin

      Maria Kendziorek

    • 13. Regulation of ROMK2 Channel Activity by Acidic Lipids: Insights from Proximity Biotinylation and Molecular Docking Studies

      Piotr Koprowski

    • 14. Neuronostatin, but not somatostatin modulates proliferation and differentiation of rat primary brown preadipocytes

      Małgorzata Krążek

    • 15. Loss of unconventional myosin VI affects lipid metabolism in hindlimb skeletal muscle

      Lilya Lehka

    • 16. Secosteroid hormone vitamin D regulates lipid metabolism genes via genomic and non-genomic pathways in squamous cell carcinoma cells – analyses of transcriptomic data

      Anna Olszewska

    • 17. Analysis of very long chain fatty acids in lung in a mouse model of IKSHD disease using GC-MS

      Agata Zwara

    • 18. Primary biliary cholangitis symptoms are reduced in liver specific Mcpip1 knock- out mice after treatment with Lactobacillus rhamnosus

      Katarzyna Trzos

  • Session 2 - From lipids to immune response

    Tomasz Wypych (chair)

    • Keynote lecture - Cardiolipin remodellin by Tafazzin controls inflammatory T cell responses

      Martin Vaeth

    • EMBO Young Investigator Lecture - Intestinal intraepithelial lymphocytes regulate intestinal and organismal metabolism

      Mahima Swamy

    • Short talk – Nutritional iron deficiency elicits unique metabolic adaptations of splenic red pulp macrophages

      Raghunandan Mahadeva

    • Short talk – Can lipids disturb the beneficial effect of Lactobacillus strains through an altered profile of bacterial proteins?

      Anna Maria Ogrodowczyk

    • Flash talk – In search of lipid mediator fingerprint reflecting endothelial dys function in murine models; comparison of bioanalysis of free and esterified fractions

      Agnieszka Kij

    • Flash talks – Metabolite X modulates metabolism of the lung during inflammation

      Magdalena Wolska

Friday

  • Session 3 - Lipid metabolism and signaling – role in cancer and beyond

    Magdalena Wit (chair)

    • Keynote lecture - Targeting Lipid Metabolism in Cancer

      Almut Schulze

    • EMBO Young Investigator Lecture -A chemical proteomics approach towards mapping lipid pathways

      Siddhesh Kamat

    • Short break

    • Short talk – Metabolic adaptations triggered by impairment of cytochrome c oxidase

      Alena Pecinova

    • Short talk – Lipid metabolism disorders in colorectal cancer

      Tomasz Śledziński

    • Short talk – Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier

      Mariana Tsap

    • Short talk – Advances in lipidomics for disease research

      Tomas Cajka

    • Flash talks – The role of HAX1 protein in lipid metabolism and lipid droplet formation in cancer cells and its impact on metastasis

      Ewa Grzybowska

    • Flash talks – The changes in lipid metabolism in metastatic melanoma cells resistant to BRAF/MEK inhibitors

      Magdalena Kot

    • Flash talks – The effect of LXR or SERCA2 activation on liver metabolism and diet-induced steatohepatitis in Mice

      Adam Olichwier

  • Snack break and Poster session 2

    • 19. In search of lipid mediator fingerprint reflecting endothelial (dys)function in murine models; comparison of bioanalysis of free and esterified fractions

      Agnieszka Kij

    • 20. The role of HAX1 protein in lipid metabolism and lipid droplet formation in cancer cells and its impact on metastasis

      Ewa Grzybowska

    • 21. The changes in lipid metabolism in metastatic melanoma cells resistant to BRAF/MEK inhibitors

      Magdalena Kot

    • 22. Unraveling the Role of MK5 in the Regulation of Skeletal Muscle Biology

      Carlos Acosta

    • 23. Unraveling molecular mechanism and metabolic consequences of the ERK3/MK5-dependent signaling in adipose tissue

      Katia Al Ghoz

    • 24. Western Diet's impact: from NAFLD and Liver Damage to Alzheimer's Development via the Liver-Brain Axis

      Justyna Domańska

    • 25. Inhibition of Protein Kinase D2 in the intestine protects against hyperlipidemia and atherosclerosis

      Filip Dziaczkowski

    • 26. Changes in serum fatty acid profile after orthotopic liver transplant

      Aleksandra Hliwa

    • 27. Diacylglycerol kinase-ε determines pro-inflammatory response of macrophages to LPS

      Aneta Hromada-Judycka

    • 28. Tumours of different invasiveness secrete small extracellular vesicles of distinct lipid composition influencing CD1a-restricted T cell responses

      Mikołaj Klimczuk

    • 29. Meeting Human Needs: The Power of Transgenic Camelina sativa

      Sylwia Klińska-Bąchor

    • 30. Metabolite X modulates metabolism of the lung during inflammation

      Magdalena Wolska

    • 31. Ultrastructural defects in multiple cell types in zebrafish model of Niemann-Pick type C disease

      Małgorzata Korzeniowska

    • 32. Inhibition of synthesis of very long chain fatty acids enhance apoptosis in primary cultures of glioblastoma multiforme

      Oliwia Lange

    • 33. Effect of fatty acids synthesized by ELOVL3 on skeletal muscle development

      Viktor Navrulin

    • 34. The effect of LXR or SERCA2 activation on liver metabolism and diet-induced steatohepatitis in mice

      Adam Olichwier

    • 35. The changes in lipid metabolism in endometrial cancer

      Yelyzaveta Razghonova

    • 36. ERK3 deletion promotes Mitochondrial function and Oxidative Capacity in Skeletal Muscle

      Abdus Saboor Shah

    • 37. Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier

      Halyna Shcherbata

    • 38. Interactions of small RNA with lipids rafts in plasma membrane of neuroblastoma cells

      Joanna Zaziąbło

    • 39. The impact of HDL subpopulations on the changes of VLDL cholesterol during lipoprotein lipase (LPL)-mediated catabolism

      Ewa Wieczorek-Breitzke

    • 40. Optical diffraction tomography for lipid droplets imaging

      Marzejon Marcin

  • Session 4 - Lipids in metabolic diseases

    Mariusz Więckowski (chair)

    • Keynote lecture - Addressing heterogeneity and the role of genetics in patients with MASLD

      Marcin Krawczyk

    • Long talk - Platelet-derived lipids promote insulin secretion of pancreatic β cells

      Katarzyna Kolczyńska Matysiak

    • Short talk – Western diet impairs liver function but does not lead to obesity or diabetes in bank voles

      Alaa Hseiky

  • Closing remarks, Short talks, and Poster prizes

    Agnieszka Dobrzyń
    Grzegorz Sumara

  • Open Scientific Picnic of the Nencki Institute

    • A brief history of the Art and Science projects 2017-2024

      Adam Szewczyk

    • Presentation of the Jan Dembowski Prize, awards for Phd Students and for science popularisation

    • Picnic in the Patio

Speakers

  • Almut Schulze

    German Cancer Research Center (DKFZ)
    Heidelberg, Germany

  • James Olzmann

    Department of Nutritional Sciences & Toxicology, University of California
    Berkeley, USA

  • Martin Vaeth

    Würzburg Institute of Systems Immunology, Max Planck Research Group, JMU
    Würzburg, Germany

  • Marcin Krawczyk

    Universitätsklinikum des Saarlandes
    Homburg, Germany

  • Toni Petan

    Jozef Stefan Institute
    Ljubljana, Slovenia

  • Mahima Swamy

    University of Dundee
    Dundee, United Kingdom

  • Siddhesh Kamat

    Indian Institute of Science Education and Research
    Pune, India

  • Katarzyna Kolczyńska Matysiak

    Dioscuri Centre for Metabolic Diseases, Nencki Institute of Experimental Biology, PAS
    Warsaw, Poland

Organizers

  • Agnieszka Dobrzyń

    Nencki Institute of Experimental Biology, PAS
    Warsaw, Poland

  • Grzegorz Sumara

    Nencki Institute of Experimental Biology, PAS
    Warsaw, Poland

  • Tomasz Wypych

    Nencki Institute of Experimental Biology, PAS
    Warsaw, Poland

  • Mariusz Więckowski

    Nencki Institute of Experimental Biology, PAS
    Warsaw, Poland

  • Magdalena Wit

    Nencki Institute of Experimental Biology, PAS
    Warsaw, Poland

  • Olga Sumara

    Nencki Institute of Experimental Biology, PAS
    Warsaw, Poland

  • Anna Bombińska

    Nencki Institute of Experimental Biology, PAS
    Warsaw, Poland

Sponsors

Info

Venue

CN Conference Hall at Nencki Institute of Experimental Biology of the Polish Academy of Sciences (3 Pasteur Street, 02-093 Warsaw, Poland).

How to get to Nencki Institute?

By bus

From the airport

From “Lotnisko Chopina – Przyloty“ bus stop (Arrivals) you might take a bus 175 (Pl.Piłsudskiego direction) or bus 188 (Gocławek Wschodni direction). Trip should take 16 minutes. Get off at “Szpital Banacha” bus stop at Żwirki i Wigury Street. From there it is less than a 10 – minute walk to the Institute

You can buy a ticket from the ticket machine either at a bus stop or in a bus. Only card payments are accepted. A 20-minute ticket costs 3,40PLN.

From train station

You might take a bus 521 from “Dw. Centralny“ bus stop (Szczęśliwice direction) and get off at “Och-Teatr” bus stop at Grójecka Street. From there it is less than a 5 – minute walk to the Institute.

By tram

From the central train station you might take a tram 7, 9 or 25 from “Dw.Centralny” tram stop (P+R Al.Krakowska or Banacha direction) and get off at “Och-Teatr” tram stop at Grójecka Street. From there it is less than a 5 – minute walk to the Institute.

By taxi

You might catch a taxi cab outside the terminal or central train station.

You can also call any of the taxi corporations: Ele TAXI +48 22 811 11 11, Radio Taxi +48 22 19191, WAWA Taxi +48 22 333 4444; SAWA Taxi +48 22 644 44 44; Super Taxi +48 22 19 622.The cost of the ride from the airport to the Institute should be approximately 12 EUR (50 PLN). The ride should take 10-15 minutes.

Accommodation (suggestions)

General info

  • Official currency: polish zloty (PLN)
  • COVID-19 travel restrictions were lifted in Poland. Therefore, providing proof of vaccination, recovery from COVID-19 or a negative test result is not required. For more info visit reopen.europa.eu
  • Electricity: 220 ~ 230V, 50 Hz

Accessibility

We strive to host accessible event that enable all individuals, including individuals with disabilities, to engage fully. For inquiries about accessibility, please contact conference2024@nencki.edu.pl

About poster session

  • Poster size: max. A0
  • Poster orientation: vertical
  • Language of the talks and posters: English

If your poster is accompanied by Flash Talk please prepare 3-minute presentation and upload it to the desktop before your session starts.

Contact

Nencki Institute of Experimental Biology of the Polish Academy of Sciences
3 Pasteur Street, 02-093 Warsaw, Poland
conference2024@nencki.edu.pl